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KMID : 0811719990030030283
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Korean Journal of Physiology & Pharmacology
1999 Volume.3 No. 3 p.283 ~ p.292
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Selective Cytotoxicity of a Novel Platinum (II) Coordination Complex on Human Gastric Cancer Cell Lines and Normal Kidney Cells
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Jee-Chang Jung
Young-Kyu Kim 1Sung-Vin Yim/Seung-Joon Park/Joo-Ho Chung/Sung-Goo Chang/Kyung-Tae Lee/Young-Soo Rho
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Abstract
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We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)] 2NO3(PC) was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant (MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less than those of cisplatin in rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues using MTT assay, [3H]?thymidine uptake and glucose consumption tests. Based on these results, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.
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KEYWORD
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Selective cytotoxicity, Nephrotoxicity, Platinum coordination complex,
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